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Self-Propagating, Molecular-Level Polymorphism in Alzheimer's -Amyloid Fibrils

✍ Scribed by Petkova, A. T.


Book ID
118269125
Publisher
American Association for the Advancement of Science
Year
2005
Tongue
English
Weight
461 KB
Volume
307
Category
Article
ISSN
0036-8075

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We demonstrate a new method for investigating the structure of self-associating biopolymers using dipolar recoupling NMR techniques. This approach was applied to the study of fibrillar beta-amyloid (Abeta) peptides (the primary component of the plaques of Alzheimer's disease) containing only a singl