Self-optimization of binding sites by Ni(II) ion on carboxypyrazine-containing poly(ethylenimine)
✍ Scribed by Junghun Suh; Sang Hyun Hong
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 135 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0887-624X
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✦ Synopsis
To test the concept of self-optimization of own binding site by a metal ion, host molecules for Ni(II) ion were built on poly(ethylenimine) (PEI) by using the ethylenediamine portions of PEI and 2-carboxypyrazinyl (CP) group. Two derivatives of PEI containing CP were prepared: one by random acylation of PEI with pyrazine-2,5-dicarboxylic acid mono-(2,5-dioxo-pyrrolidin-1-yl) ester (PC-DP), and the other by acylation of PEI with PC-DP in the presence of Ni(II) ion. Between these two CP derivatives of PEI, Ni(II) binding ability was more than 10 3 times greater for the latter. Optimization by Ni(II) ion of its own binding site built on the polymer was attributed to the preassemblage of PC-DP and PEI with Ni(II) ion and the subsequent attack at PC-DP by an amino group of PEI located in an optimal position.