✦ LIBER ✦
Self-Assembly Pluronic and β-Cyclodextrin to Hollow Nanospheres for Enhanced Gene Delivery
✍ Scribed by Min-Min Fan; Xi Zhang; Jie Qin; Bang-Jing Li; Xun Sun; Sheng Zhang
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 307 KB
- Volume
- 32
- Category
- Article
- ISSN
- 1022-1336
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
This paper studies a kind of hollow nanospheres prepared by self‐assembly β‐cyclodextrins (β‐CDs) and poly(ethylene oxide)‐poly(propylene oxide)‐poly(ethylene oxide) (pluronic F127) for gene delivery. It was found that this kind of hollow nanospheres enable load PEI10K/DNA and the resulting F127NH~2~βCD/(PEI10K/DNA) with 0.08 µg/well DNA display equal or higher gene delivery capability compared to PEI10K/DNA with 1 µg/well DNA in the absence or presence of serum. The cytotoxicity of the nanospheres was over 100 times lower than that of PEI10K.
magnified image