Self-Assembly of Thermally Responsive Nanoparticles of a Genetically Encoded Peptide Polymer by Drug Conjugation

Multifunctioning pH-responsive nanoparti

Multifunctioning pH-responsive nanoparticles from hierarchical self-assembly of polymer brush for cancer drug delivery

✍ Youqing Shen; Yihong Zhan; Jianbin Tang; Peisheng Xu; Patrick A. Johnson; Maciej 📂 Article 📅 2008 🏛 American Institute of Chemical Engineers 🌐 English ⚖ 768 KB

## Abstract Polymer nanoparticles are extensively explored as drug carriers but they generally have issues of premature burst drug release, slow cellular uptake, and retention in acidic intracellular compartments. Herein, we report multifunctioning three‐layered nanoparticles (3LNPs) that can overc