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Self-assembly of poly(ethylene glycol)-based block copolymers for biomedical applications

✍ Scribed by Hidenori Otsuka; Yukio Nagasaki; Kazunori Kataoka

Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
622 KB
Volume
6
Category
Article
ISSN
1359-0294

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✦ Synopsis

Nanostructure fabrication from block copolymers is discussed in this review paper. Particularly, novel approaches for the Ε½ . Ε½ . construction of functionalized poly ethylene glycol PEG layers on surfaces were focused to attain the specific adsorption of a target protein through PEG-conjugated ligands with a minimal non-specific adsorption of other proteins. Furthermore, surface organization of block copolymer micelles with cross-linking cores was described from the standpoint of preparation of a new functional surface-coating with a unique macromolecular architecture. The micelle-attached surface and the thin hydrogel layer made by layered micelles exhibited non-fouling properties and worked as a reservoir for hydrophobic reagents. These PEG-functionalized surface in brush form or in micelle form can be used in diverse fields of medicine and biology to construct high-performance medical devices including scaffolds for tissue engineering and matrices for drug delivery systems.

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