Self-assembling urea-based peptidomimetics: A simple one-step synthesis and crystal structure of Core β-alanyl ureylene retro-bispeptides (MeOAaa[NHCONH]CH2CH2CONHAaaOMe; Aaa = amino acid A)

✍ Scribed by Darshan Ranganathan; Sunita Kurur; K.P. Madhusudanan; Isabella L. Karle

• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 223 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)00960-x

✦ Synopsis

A novel family of urea-based peptidomimetics containing 13-alanyl unit at the core has been synthesized by a simple one-step procedure. Solid state structures of some representative examples have shown soft-assembly into highly ordered, extended hydrngen-bonded chains and ribbons with modest NLO activity.