✦ LIBER ✦

Self-Assembling Diblock Copolymers of Poly[N-(2-hydroxypropyl)methacrylamide] and a β-Sheet Peptide

✍ Scribed by Larisa Cristina Radu; Jiyuan Yang; Jindřich Kopeček

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 590 KB
Volume: 9
Category: Article
ISSN: 1616-5187
DOI: 10.1002/mabi.200800193

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The self‐assembly of hybrid diblock copolymers composed of poly(HPMA) and β‐sheet peptide P11 (CH~3~CO‐QQRFQWQFEQQ‐NH~2~) blocks was investigated. Copolymers were synthesized via thiol‐maleimide coupling reaction, by conjugation of semitelechelic poly(HPMA)‐SH with maleimide‐modified β‐sheet peptide. As expected, CD and CR binding studies showed that the peptide block imposed its β‐sheet structural arrangement on the structure of diblock copolymers. TEM and AFM proved that peptide and these copolymers had the ability to self‐assemble into fibrils.

magnified image

📜 SIMILAR VOLUMES

ChemInform Abstract: Demonstration of en

ChemInform Abstract: Demonstration of endo-cis-(2S,3R)-Bicyclo[2.2.1]hept-5-en-2,3-dicarbonyl Unit as a Reverse-Turn Scaffold and Nucleator of Two-Stranded Parallel β-Sheets: Design, Synthesis, Crystal Structure, and Self-Assembling Properties of Norborneno Peptide Analogues.

✍ D. RANGANATHAN; V. HARIDAS; S. KURUR; A. THOMAS; K. P. MADHUSUDANAN; R. NAGARAJ; 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v