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Self-assembled siRNA–PLGA conjugate micelles for gene silencing

✍ Scribed by Soo Hyeon Lee; Hyejung Mok; Yuhan Lee; Tae Gwan Park

Book ID
113693577
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
756 KB
Volume
152
Category
Article
ISSN
0168-3659

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Cholesterol-conjugated H 5 R 10 and H 10 R 10 oligopeptides (HR15-Chol and HR20-Chol) were designed and synthesized. These amphiphilic oligopeptides were able to self-assemble into cationic micelles in aqueous solution at low concentrations, and their critical micelle concentrations in sodium acetat