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Self-Assembled pH-Sensitive Nanoparticles: A Platform for Oral Delivery of Protein Drugs

✍ Scribed by Kiran Sonaje; Kun-Ju Lin; Jiun-Jie Wang; Fwu-Long Mi; Chiung-Tong Chen; Jyuhn-Huarng Juang; Hsing-Wen Sung

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
596 KB
Volume
20
Category
Article
ISSN
1616-301X

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## Abstract Polymer nanoparticles are extensively explored as drug carriers but they generally have issues of premature burst drug release, slow cellular uptake, and retention in acidic intracellular compartments. Herein, we report multifunctioning three‐layered nanoparticles (3LNPs) that can overc