✦ LIBER ✦

Selenium labeled fatty acids as potential myocardial imaging agents

✍ Scribed by Samy A. Sadek; Garo P. Basmadjian

Publisher: John Wiley and Sons
Year: 1983
Tongue: French
Weight: 270 KB
Volume: 20
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580200406

No coin nor oath required. For personal study only.

✦ Synopsis

S i x 75Se labeled fatty acid analogues were synthesized : 3-selena-[ Selpentadecanoic acid, 4-selenac Selhexadecanoic acid, 3-~elena[~~Se]heptadecanoic acid, ~-~e l e n a [ ~~S e ~o c t a d e c a n o i c acid, 3-selenac Selnonadecanoic acid, and 4-selenaC Seleicosanoic acid. Selenious acid was reduced with NaBH in buffer pH 6.0. The nucleophile produced, NaSeH . was reacted with different alkyl halide to form the corresponding selenol. To this was added an aqueous solution of the sodium salt of either iodoacetic acid or 3-bromopropionic acid to form the sodium salt of the desired fatty acid . The free fatty acids were extracted in ether after acidification of the solution.

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