Selenium inhibits high glucose-induced cyclooxygenase-2 and P-selectin expression in vascular endothelial cells

High glucose increases expression of cyc

High glucose increases expression of cyclooxygenase-2, increases oxidative stress and decreases the generation of nitric oxide in mouse microvessel endothelial cells

✍ Mohamad Aljofan; Hong Ding 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 231 KB

Hyperglycaemia is a key factor that contributes to the development of diabetes-related microvascular disease. Both cyclooxygenase I and cyclooxygenase II are expressed in endothelial cells and play key roles in the regulation of cardiovascular function. In the current study we tested the hypothesis