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Selenium heterocycles X: Synthesis and antibacterial activity of pyridyl-1,2,3-thiadiazoles and pyridyl-1,2,3-selenadiazoles

✍ Scribed by I. Lalezari; A. Shafiee; S. Yazdany

Publisher: John Wiley and Sons
Year: 1974
Tongue: English
Weight: 180 KB
Volume: 63
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600630434

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✦ Synopsis

acidic carboxylic group of aspirin may be achieved by making derivatives similar to Compound I. One possible advantage of a compound such as I is that the mucous membranes of the stomach are in contact with a neutral molecule. As I dissolves, however, it will rapidly hydrolyze, generating aspirin in solution. The mechanism of hydrolysis of I was shown to proceed by a classical SN1-type reaction.

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