✦ LIBER ✦
Selenium dioxide oxidation of 3-methyl-4,5,6,7-tetrafluoroindoles: an efficient route to tetrafluoro analogs of 3-formyl and 3-acetoxymethylindole systems
✍ Scribed by Makoto Fujita; Iwao Ojima
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 248 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
smary : Selenium dioxide oxidations of 3-methyl-4,5,6,7-tetrafluoroindoles gave S-formy or 3-acetoxymethyltetrafluoroindoles in unexpectedly high selectivities, which turned out to serve as useful intermediates for the syntheses of tetrafluoro analogs of tryptophan, tryp-tam&e and indole acetic acid. Recently, it has been shown that fluorinated analogs of naturally occurring biologically active compounds often exhibit unique physiological activities.2