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Selectivity of repaglinide and glibenclamide for the pancreatic over the cardiovascular KATPchannels

✍ Scribed by D. Stephan; M. Winkler; P. Kühner; U. Russ; U. Quast

Book ID
105818423
Publisher
Springer
Year
2006
Tongue
English
Weight
263 KB
Volume
49
Category
Article
ISSN
0012-186X

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Effects of the hypoglycaemic drugs repag
Effects of the hypoglycaemic drugs repaglinide and glibenclamide on ATP-sensitive potassium-channels and cytosolic calcium levels in Β TC3 cells and rat pancreatic beta cells
✍ J. Gromada; S. Dissing; H. Kofod; J. FrØkjÆr-Jensen 📂 Article 📅 1995 🏛 Springer 🌐 English ⚖ 807 KB

The present study demonstrates the action of the hypoglycaemic drugs repaglinide and glibenclamide in cultured newborn rat islet cells and mouse flTC3 cells. In cell-attached membrane patches of newborn rat islet cells repaglinide (10 nmol/ 1) and glibenclamide (20 nmol/1) decrease the open probabil