✦ LIBER ✦

Selectivity of N-aroyl-N′-arylthioureas towards 2-(1,3-dioxo-1H-inden-2(3H)-ylidene)malononitrile. New synthesis of (Z)-N-((E)-4-amino-1-aryl-5-cyano-6-oxo-1H-indeno[1,2-d][1,3]- thiazepin-2(6H)-ylidene)-4-arylamides of antitumor and antioxidant activities

✍ Scribed by Ashraf A. Aly; Alan B. Brown; Mohamed Ramadan; Mohamed Abdel-Aziz; Gamal El-Din A. A. Abuo-Rahma; Mohamed F. Radwan; Amira M. Gamal-Eldeen

Book ID: 102343057
Publisher: Journal of Heterocyclic Chemistry
Year: 2010
Tongue: English
Weight: 217 KB
Volume: 47
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.344

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✦ Synopsis

Abstract

magnified image The reaction between N‐aroyl‐N′‐arylthioureas with 2‐(1,3‐dioxoindan‐2‐ylidene)malononitrile furnished indeno[1,2‐d][1,3]thiazepines in 70–85% yields. The mechanism of the products' formation is discussed. Some of the products showed effective antitumor and antioxidant activities. The results revealed that compound indenothiazepine derivative showed a high inhibition of the cell growth of Hep‐G2 cells is compared with the growth of untreated control cells, as concluded from their low IC~50~ value 21.73 μ__M__. On the other hand, two indenothiazepine derivatives have an effective antioxidant activity with SC~50~ values of 62.5 m__M__ and 87.4 m__M__, respectively. J. Heterocyclic Chem., (2010).

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