Facile synthesis of trifluoromethyl carb
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Yuelian Xu; William R. Dolbier Jr.
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Article
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1998
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Elsevier Science
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French
⚖ 207 KB
1,1-Bis(dimethylamino)-2,2,2-trifluoroethane is an excellent synthetic building-block replacement for trifluoroacetaldehyde in condensation reactions with ketones using 36% aqueous HCI catalysis. Moderate to good yields (43-68%) of trifluoromethyl carbinols are obtained with symmetric and unsymmetri