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Selective targeting of DPC4 (deleted in pancreatic cancer locus 4)-deficient pancreatic cancer cells

โœ Scribed by Andrew D. Westwell

Book ID
113568717
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
51 KB
Volume
12
Category
Article
ISSN
1359-6446

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Homozygous deletions inactivate DCC, but
Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers
โœ Werner Hilgers; Jason J. Song; Marianne Haye; Ralph R. Hruban; Scott E. Kern; Er ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 88 KB

Loss of heterozygosity (LOH) of chromosome arm 18q is frequent in gastrointestinal cancers. Over 90% of pancreatic carcinomas have 18q LOH. Bi-allelic inactivation of the MADH4/DPC4/SMAD4 gene at 18q21.1 is seen in about half of pancreatic carcinomas with 18q LOH. In the remaining tumors with 18q LO