Selective Synthesis of Polyfunctionalized Pyrido[2,3- b ]indoles by Multicomponent Domino Reactions
✍ Scribed by Hu, Jun-Die; Cao, Cheng-Pao; Lin, Wei; Hu, Ming-Hua; Huang, Zhi-Bin; Shi, Da-Qing
- Book ID
- 125856726
- Publisher
- American Chemical Society
- Year
- 2014
- Tongue
- English
- Weight
- 656 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
AbstractÐDiels±Alder reactions between 2-or 3-vinylpyrrolo[2,3-b]pyridine with various dienophiles were investigated. The pyrido[2,3b]indole adducts 9 and 13 obtained led us to the preparation of potential cytotoxic agents 19 and 20.
An efficient and versatile synthesis of substituted and annelated pyrido[2,3-b]indoles (e~-carboline) involving conjugate displacement on at-oxoketene dithioacetals by 1-methyl-2-oxoindole enolate anion and subsequent cyclization of the adducts in the presence of ammonium acetate has been described.
## Abstract The synthesis of the title compounds 5__H__, 11__H__‐pyrido[2′,3′:2,3]thiopyrano[4,3‐__b__]indoles was accomplished by the Fischer indole cyclization of some 2,3‐dihydrothiopyrano[2,3‐__b__]pyridin‐4(4__H__)‐one phenylhydrazones and 7‐methyl‐2,3‐dihydrothiopyrano[2,3‐__b__]pyridin‐4(4__