Straightforward Synthesis of 1-Alkyl-2-(trifluoromethyl)aziridines Starting from 1,1,1-Trifluoroacetone. -The straightforward approach towards the synthesis of aziridines (IV) starts from trifluoroacetone (I) via imination, α-chlorination, hydride reduction, and ring closure. Additional information
✦ LIBER ✦
Selective Synthesis of Functionalized Trifluoromethylated Pyrrolidines, Piperidines, and Azepanes Starting from 1-Tosyl-2-(trifluoromethyl)aziridine
✍ Scribed by Dolfen, Jeroen; Kenis, Sara; Van Hecke, Kristof; De Kimpe, Norbert; D'hooghe, Matthias
- Book ID
- 124087839
- Publisher
- John Wiley and Sons
- Year
- 2014
- Tongue
- English
- Weight
- 311 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0947-6539
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Selective One-Step Synthesis of Enantiopure cis-2,5-Disubstituted Pyrrolidines or cis-3,6-Disubstituted Piperidines from the (2R,2'R)-(1,2-Ethanediyl)bis-aziridine. -Chromatographic purification of the optically active bis-aziridine (I) results in a 5-exo-tet aminocyclization to the cis-2,5-disubst