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Selective sparing of hippocampal CA3 cells following in vitro ischemia is due to selective inhibition by acidosis

โœ Scribed by Tobias Cronberg; Kimmo Jensen; Anna Rytter; Tadeusz Wieloch


Book ID
110100413
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
418 KB
Volume
22
Category
Article
ISSN
0953-816X

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โœ Linda K. Friedman ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 982 KB

Kainic acid (KA) induces status epilepticus and delayed neurodegeneration of CA3 hippocampal neurons. Downregulation of glutamate receptor 2 (GluR2) subunit mRNA [the โฃ-amino-3-hydroxy-5methyl-4-isoxazole-propionic acid (AMPA) subunit that limits Ca 2ุ‰ permeability] is thought to a play role in this