β Scribed by Kevin Struhl
No coin nor oath required. For personal study only.
Transcription factor TFIID, a central component of the eukaryotic RNA polymerase II transcription machinery, is a multiprotein complex containing the TATAβbinding protein (TBP) and TBPβassociated factors (TAFs). In vitro, TAFs are required for the response to activator proteins, but they are dispensible for basal transcription. However, recent work in yeast cells indicates that TAFs are not generally required for transcriptional activation, but rather have selective effects on gene expression. Molecular mechanisms for these observations are considered.
π SIMILAR VOLUMES
## Abstract The insulinβlike growth factor (IGF) axis is a complex system composed of 2 mitogenic ligands, IGFβI and βII, 2 receptors, IGFβ1R and IGFβ2R, and 6 binding proteins, IGFBPβ1 to β6. The IGFBPs exert their actions through their regulation of IGF bioavailability for IGF receptors. In addit