Selective retrograde labeling with D-[3H]-aspartate in the monkey olivocerebellar projection

✍ Scribed by C. Matute; L. Wiklund; P. Streit; M. Cuénod

• Book ID: 104679742
• Publisher: Springer-Verlag
• Year: 1987
• Tongue: English
• Weight: 871 KB
• Volume: 66
• Category: Article
• ISSN: 0014-4819
• DOI: 10.1007/bf00243320

✦ Synopsis

The specificity of D-[3H]-aspartate as a retrograde marker was investigated following large injections of this tritiated amino acid in the monkey cerebellar cortex. Retrogradely labeled neurons were found exclusively in the inferior olive, a fact which is consistent with previous studies in the rat. These results show that D-[3H]-aspartate is a selective tracer that might also be useful to delineate excitatory pathways using glutamate and/or aspartate as neurotransmitter(s) in the monkey brain.