𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Selective Reduction of Amides to Amines by Boronic Acid Catalyzed Hydrosilylation

✍ Scribed by Li, Yuehui; Molina de La Torre, Jesús A.; Grabow, Kathleen; Bentrup, Ursula; Junge, Kathrin; Zhou, Shaolin; Brückner, Angelika; Beller, Matthias

Book ID
120998705
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
543 KB
Volume
52
Category
Article
ISSN
0044-8249

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Selective reduction of secondary amides
Selective reduction of secondary amides to amines in the presence of tertiary amides
✍ Byung H. Lee; Michael F. Clothier 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 89 KB

Secondary amides activated with a Cbz group can be reduced to their corresponding hemiaminals using lithium borohydride. Hydrogenation then removes the Cbz and hydroxyl groups to produce the related amine. Tertiary amides are not affected.