𝔖 Bobbio Scriptorium
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SELECTIVE REDUCTION AND ALKYLATION OF THE COOH-TERMINAL DISULFIDE BRIDGE IN BOVINE GROWTH HORMONE

✍ Scribed by Gráf, László ;Li, Choh Hao ;Bewley, Thomas A.


Book ID
115097195
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
488 KB
Volume
7
Category
Article
ISSN
0367-8377

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## Abstract The 45‐residue C‐terminal EGF‐like domain in human blood coagulation factor IX has been synthesized by a 2‐step method to form selectively 3 disulfide bridges. Four out of 6 cysteines are blocked with either trityl or 4‐methyl‐benzyl, and the remaining 2 cysteines are blocked with aceta