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Selective procedure for the conversion of alcohols into alkyl iodides with and NaI at room temperature

✍ Scribed by Jitendra R. Satam; Radha V. Jayaram


Book ID
119216197
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
338 KB
Volume
9
Category
Article
ISSN
1566-7367

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Alcohols and weakly acidic phenols which do not react with diazomethane can be methylated in the presence of acid catalysts 2.3 , but certain hindered alcohols 2,3 and phenols 3 react with difficulty or not at all. We describe here the use of sodium hydride / methyl iodide in tetrahydrofuran (THF) a