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Selective Phenolic Acylation of 10-Hydroxycamptothecin Using Poly (Ethylene Glycol) Carboxylic Acid.

✍ Scribed by Richard B. Greenwald; Yun H. Choe; Dechun Wu


Book ID
101939545
Publisher
John Wiley and Sons
Year
2003
Weight
54 KB
Volume
34
Category
Article
ISSN
0931-7597

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✍ Anita Slavica; Iskandar Dib; Bernd Nidetzky 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 253 KB 👁 2 views

## Abstract Covalent modification of purified __Trigonopsis variabilis__ D‐amino acid oxidase using maleimide‐activated poly(ethylene glycol) 5000 yielded a stable bioconjugate in which three surface‐exposed cysteine side chains were selectively derivatized. Compared with the native enzyme, the PEG