Selective oxidation of terminal isopropyl groups to tertiary alcohols by electrochemical methodology

✍ Scribed by Shojiro Maki; Katsuhiro Konno; Hiroaki Takayama

• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 198 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)01650-x

✦ Synopsis

Selective oxidation of terminal isopropyl groups to the corresponding tertiary alcohols by ma electrochemical method is described. Under the conditions using the Tl(I'FA)s-hematopoqahyrin-O2cathodic nxluction system, several substrates such as cholesterol (1) madGrundmann's alcohol (3) gave the corresponding tertiary alcohols 2 and4, respectively, in reasonable yield.