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Selective O-demethylation of catechol ethers. Comparison of boron tribromide and iodotrimethylsilane

✍ Scribed by Vickery, E. Harold; Pahler, Leon F.; Eisenbraun, Edmund J.


Book ID
120587142
Publisher
American Chemical Society
Year
1979
Tongue
English
Weight
403 KB
Volume
44
Category
Article
ISSN
0022-3263

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Selective O-demethylation of the ortho methyl catecholate of N,N',N"-tris-(2,3dimethoxybenzeyl)-l,l,l-tris-(L-methioninemehyl)-ethane (2) has been accomplished by boron tribromide. The intramolecular nucleophilic attack of divalent sulphur on methyl enhance this cleavage, favours this selctivity and