Selective monotetrahydropyranylation of 1,n-diols catalyzed by aqueous acids
β Scribed by Takeshi Nishiguchi; Seiji Hayakawa; Yoshihiro Hirasaka; Masahiko Saitoh
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 57 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The reaction of internal 1,2-diols with catalytic n-Bu 2 SnO, p-TsCl (1.05 equiv.) and Et 3 N (1.1 equiv.) led to selective monotosylation. In the case of cyclic substrates, the cis-1,2-diol moiety appeared best suited for optimal results, supporting the intermediacy of a five-membered chelate.
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