Selective Modulation of Matrix Metalloproteinase 9 (MMP-9) Functions via Exosite Inhibition
β Scribed by Lauer-Fields, J. L.; Whitehead, J. K.; Li, S.; Hammer, R. P.; Brew, K.; Fields, G. B.
- Book ID
- 115526832
- Publisher
- The American Society for Biochemistry and Molecular Biology
- Year
- 2008
- Tongue
- English
- Weight
- 253 KB
- Volume
- 283
- Category
- Article
- ISSN
- 0021-9258
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Matrix metalloproteinases (MMPs) are responsible for the remodeling of the extracellular matrix throughout the body. Inhibitors of these enzymes have been suggested as potential therapeutic agents for use in treatment of cancer. Our observations showed that cleistanthin A, a diphyllin glycoside from
## Abstract Matrix metalloproteinaseβ9 (MMPβ9) is implicated in the invasion and metastasis of breast cancer cells. We investigated the modulatory effects of nitric oxide (NO) on the 12β__O__βtetradecanoylphorbol 13βacetate (TPA)βinduced MMPβ9 expression in MCFβ7 cells. Different chemical NO donors