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Selective metal-catalyzed autoxidation of 2-arylpropionaldehydes. An improved synthesis of ibuprofen

✍ Scribed by Riley, D. P.; Getman, D. P.; Beck, G. R.; Heintz, R. M.


Book ID
121291647
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
553 KB
Volume
52
Category
Article
ISSN
0022-3263

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Alkylation of a phenol OH in the presence of a free benzimidazole NH was investigated and found to be highly dependent on the substitution of the benzimidazole and phenol rings. The modification of our original synthesis of 2-arylbenzimidazole H 4 receptor ligands has resulted in improved yields and