Selective phenol alkylation for an impro
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Brad M. Savall; Jill R. Fontimayor; James P. Edwards
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Article
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2009
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Elsevier Science
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French
β 197 KB
Alkylation of a phenol OH in the presence of a free benzimidazole NH was investigated and found to be highly dependent on the substitution of the benzimidazole and phenol rings. The modification of our original synthesis of 2-arylbenzimidazole H 4 receptor ligands has resulted in improved yields and