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Selective loss of P2Y2nucleotide receptor immunoreactivity is associated with Alzheimer’s disease neuropathology

✍ Scribed by Mitchell K. P. Lai; Michelle G. K. Tan; Sara Kirvell; Carl Hobbs; Jasinda Lee; Margaret M. Esiri; Christopher P. Chen; Paul T. Francis


Book ID
106207390
Publisher
Springer
Year
2008
Tongue
English
Weight
354 KB
Volume
115
Category
Article
ISSN
1435-1463

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## Abstract Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are common forms of dementia in the elderly associated with cholinergic dysfunction, including reductions in nicotinic acetylcholine receptors (nAChRs). In AD, astrocytes are implicated in the formation of senile plaques, one