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Selective inhibitors of death in mutant huntingtin cells

✍ Scribed by Varma, Hemant; Voisine, Cindy; DeMarco, C Todd; Cattaneo, Elena; Lo, Donald C; Hart, Anne C; Stockwell, Brent R

Book ID
109914131
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
545 KB
Volume
3
Category
Article
ISSN
1552-4450

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## Abstract ## Background Huntington's disease (HD) is an inherited neurodegenerative disorder which is caused by an expansion of a CAG repeat sequence in the HD gene. The repeat encodes an expanded polyglutamine tract in the protein huntingtin. The still unknown pathological mechanisms leading to