Selective inhibition of type a monoamine oxidase by pyrazidol
β Scribed by M. D. Mashkovskii; V. Z. Gorkin; I. V. Verevkina; V. V. Asnina; S. M. Tupikina
- Publisher
- Springer US
- Year
- 1981
- Tongue
- English
- Weight
- 278 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0007-4888
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The effects of clorgyline were compared with the effects of (-)-deprenyl using measures of rewarding hypothalamic self-stimulation, regional monoamine metabolism and monoamine oxidase activity. Male Wistar rats trained to self-stimulate at half-maximal rates with unilateral bipolar lateral hypothala
## Abstract Monoamine oxidase type B (MAOβB) was similarly active in the hypothalamus of 60βdayβold male and female Charles River rats. A single, 2 mg/kg IP injection of deprenyl, however, resulted in a significantly greater inhibition of hypothalamic MAOβB in normal males than in normal females. R