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Selective inhibition of ribonucleotide reductase by the monofunctional alkylating agent 5(1-aziridinyl)-2,4-dinitrobenzamide (CB 1954)

✍ Scribed by Michael J. Tisdale; Alan D. Habberfield


Book ID
115774910
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
814 KB
Volume
29
Category
Article
ISSN
0006-2952

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Studies on the mechanism of action of 5-
✍ T. A. Connors; D. H. Melzack πŸ“‚ Article πŸ“… 1971 πŸ› John Wiley and Sons 🌐 French βš– 470 KB

## Abstract CB 1954, a monofunctional alkylating agent, has exceptional activity against the Walker carcinoma yet is inactive against a large number of other animal tumours. A line of the Walker tumour with acquired resistance to CB 1954 was cross‐resistant to Melphalan, implying a common mechanism