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Selective inhibition of protein tyrosine phosphatase activities by H2O2 and vanadate In vitro

✍ Scribed by Dalit Hecht; Yehiel Zick

Book ID: 115765159
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 457 KB
Volume: 188
Category: Article
ISSN: 0006-291X
DOI: 10.1016/0006-291x(92)91123-8

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## Abstract __SELEX was used to create an RNA aptamer targeted to protein tyrosine phosphatase 1B (PTP1B), an enzyme implicated in type 2 diabetes, breast cancer and obesity. We found an aptamer that strongly inhibits PTP1B in vitro with a__ K__~i~ of less than 600 pM. This slow‐binding, high‐affin