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Selective inhibition of preribosomal RNA synthesis by puromycin aminonucleoside in transformed human fibroblasts: Studies of the nature of the inhibition in isolated nuclei and nucleoli

โœ Scribed by Ernest A. Albanese; George P. Studzinski


Book ID
118284247
Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
974 KB
Volume
99
Category
Article
ISSN
0021-9541

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We have studied the effect of increased intracellular levels of cyclic AMP on the growth response to platelet-derived growth factor (PDGF) of human foreskin fibroblasts in culture. It was found that forskolin, a potent stimulator of adenylate cyclase activity, inhibits the stimulatory effect of PDGF