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Selective inhibition of major drug metabolizing cytochrome P450 isozymes in human liver microsomes by carbon monoxide

โœ Scribed by T. Leemann; P. Bonnabry; P. Dayer

Book ID
118346654
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
364 KB
Volume
54
Category
Article
ISSN
0024-3205

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## Abstract Previous studies have established that chlorpyrifos (CPS), fipronil, and nonane can all be metabolized by human liver microsomes (HLM) and a number of cytochrome P450 (CYP) isoforms. However, metabolic interactions between these three substrates have not been described. In this study th