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Selective inhibition of human 3β-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer

✍ Scribed by James L. Thomas; Kevin M. Bucholtz; Balint Kacsoh


Book ID
116698592
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
491 KB
Volume
125
Category
Article
ISSN
0960-0760

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## Abstract Oestradiol (E2) stimulates the growth of hormone‐dependent breast cancer. 17β‐hydroxysteroid dehydrogenases (17β‐HSDs) catalyse the pre‐receptor activation/inactivation of hormones and other substrates. 17β‐HSD1 converts oestrone (E1) to active E2, but it has recently been suggested tha