Cell-specific expression of the diphther
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Murayama, Yoshihiko; Tadakuma, Takushi; Kunitomi, Michito; Kumai, Koichiro; Tsut
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Article
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1999
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John Wiley and Sons
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English
⚖ 297 KB
Background and Objectives: Development of the system to express a suicide gene selectively in tumor cells is essential for gene therapy. We constructed a plasmid containing the diphtheria toxin A (DTA) fragment linked to human alpha-fetoprotein (AFP) promoter and enhancer, and tested whether it can