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Selective Inhibition of Endothelin Receptor A as an Anti-angiogenic and Anti-proliferative Strategy for Human Pancreatic Cancer

✍ Scribed by Sarah Bhargava; Till Stummeyer; Birgit Hotz; O. Joe Hines; Howard A. Reber; Heinz J. Buhr; Hubert G. Hotz

Book ID
108137551
Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
142 KB
Volume
9
Category
Article
ISSN
1091-255X

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A derivative of staurosporine (CGP 41 25
A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and In vitro anti-proliferative as well as In vivo anti-tumor activity
✍ Thomas Meyer; Urs Regenass; Doriano Fabbro; Enrica Alteri; Johannes RΓΆusel; Marc πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 French βš– 632 KB

Analogues of staurosporine were synthesized and their ability to inhibit protein kinases was examined. Staurosporine is a potent but non-selective inhibitor of in vitro protein kinase C (PKC) activity (K5, 6.0 nn). The derivative CGP 41 25 I had reduced PKC activity with an IC,, of 50 nn but showed