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Selective Inhibition of Cyclooxygenase-2 with Antisense Oligodeoxynucleotide Restricts Induction of Rat Adjuvant-Induced Arthritis

✍ Scribed by Ryoji Yamada; Hajime Sano; Timothy Hla; Akira Hashiramoto; Yutaka Kawahito; Shigehiko Mukai; Masataka Kohno; Yasunori Tsubouchi; Miki Inoue; Akiko Komatsu; Ken-ichiro Inoue; Motoharu Kondo


Book ID
115585395
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
494 KB
Volume
269
Category
Article
ISSN
0006-291X

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## Abstract We have previously demonstrated that JTE‐522, a selective cyclooxygenase‐2 (COX‐2) inhibitor, inhibited development of aberrant crypt foci (ACF) in rats, a putative preneoplastic lesion in colon, and suggested its inhibitory potential in rat colon carcinogenesis. To evaluate the chemopr