Selective Inhibition of Collagen-Induced Platelet Aggregation by a Cyclic Peptide from Drymaria diandra
✍ Scribed by Pei-Wen Hsieh; Fang-Rong Chang; Chin-Chuang Wu; Kuen-Yuh Wu; Chien-Ming Li; Wei-Ya Wang; Ling-Chia Gu; Yang-Chang Wu
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- German
- Weight
- 125 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
Four cyclic peptides, diandrine A–D (1–4), were isolated from the MeOH extract of Formosan Drymaria diandra. Their structures were elucidated by chemical and spectroscopic analyses as cyclo(‐Gly^1^‐Pro^2^‐Trp^3^‐Pro^4^‐Tyr^5^‐Phe^6^‐), cyclo(‐Gly^1^‐Pro^2^‐Leu^3^‐Pro^4^‐Leu^5^‐Trp^6^‐Ser^7^‐Ser^8^‐), cyclo(Gly^1^‐Gly^2^‐Pro^3^‐Tyr^4^‐Trp^5^‐Pro^6^‐), and cyclo(Gly^1^‐Gly^2^‐Pro^3^‐Tyr^4^‐Trp^5^‐Pro^6^‐), respectively. Compounds 3 and 4 were stable conformational isomers. Cyclopeptide 1 showed a selective inhibitory effect on collagen‐induced platelet aggregation with an IC~50~ value of 44.2 μM.