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Selective Inhibition of Biosynthesis of Ribonucleic Acid in Mammalian Cells by Chromomycin A3

โœ Scribed by WAKISAKA, G.; UCHINO, H.; NAKAMURA, T.; SOTOBAYASHI, H.; SHIRAKAWA, S.; ADACHI, A.; SAKURAI, M.

Book ID
109627737
Publisher
Nature Publishing Group
Year
1963
Tongue
English
Weight
261 KB
Volume
198
Category
Article
ISSN
0028-0836

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## Abstract Three structurally related anticancer drugs, mithramycin, chromomycin A~3~, and olivomycin, showed large unexpected differences (up to more than 1000 fold) in their toxicity towards cultured cells from various species (human, Chinese hamster, Syrian hamster, and mouse). Among the cell t