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Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on acute inflammatory responses

โœ Scribed by G.A. Higgs; R.L. Follenfant; L.G. Garland


Book ID
117958823
Publisher
Nature Publishing Group
Year
1988
Tongue
English
Weight
706 KB
Volume
94
Category
Article
ISSN
0007-1188

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Effect of dihomogammalinolenic acid and
โœ L. Iversen; K. Fogh; K. Kragballe ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 478 KB

The purpose of the present study was to determine the effect of the n-6 fatty acid, dihomogammalinolenic acid (DGLA, 20 : 3, n-6) on arachidonic acid (AA) (C20:4) metabolism by human peripheral mononuclear leukocytes (HPML). After incubation of HPML with A23187 (5 ~tM) and DGLA, the cyclooxygenase (