Selective improvements in multiquality products assisted by rotated principal components
✍ Scribed by K Dyrstad
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 231 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0169-7439
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✦ Synopsis
Selective improvements in pharmaceutical multiquality products have been assisted by rotated principal components. Orthogonal and oblique rotations of principal components have been applied to evaluate data from two production process stud-Ž . ies. The purpose of the presented methods is to locate the process variables X 's that can be used to vary some quality Ž . parameters Y 's , with as minimal influence on other Y 's as possible, followed by explicit illustrations of such X-Y relations. Two procedures involving varimax rotation are used for this purpose. One, evaluate the loadings from varimax per-Ž . formed on all variables X 's and Y 's . Two, varimax performed on Y 's only, followed by linear regression of the varimax Ž . Y-scores on X 's VMLR or VPLS to evaluate the effect of X 's on certain Y-groups. The VMLR and VPLS were generally found to be more robust methods compared with varimax only. The information derived from the rotation analysis was used to adjust the relevant X-variables in linear regression models developed to estimate precise Y 's.