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Selective impairment in dendritic cell function and altered antigen-specific CD8+ T-cell responses in diet-induced obese mice infected with influenza virus

✍ Scribed by Alexia G. Smith; Patricia A. Sheridan; Raymond J. Tseng; John F. Sheridan; Melinda A. Beck


Book ID
108782383
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
418 KB
Volume
126
Category
Article
ISSN
0019-2805

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## Abstract Activation of mature CD8^+^ T cells requires recognition, __via__ the T cell receptor (TCR), of peptide + MHC (pMHC) complexes with an avidity that exceeds a designated threshold. Multiple indicators of T cell avidity have been described that provide unique information on the characteri