Selective IgA deficiency: Clinical and immunological evaluation of 50 pediatric patients

✍ Scribed by G. R. Burgio; M. Duse; V. Monafo; A. Ascione; L. Nespoli

• Publisher: Springer
• Year: 1980
• Tongue: English
• Weight: 497 KB
• Volume: 133
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00441577

✦ Synopsis

Fifty children with IgA deficiency were followed for 1 to 4 years from 1975 to 1978. Thirty-five had complete deficiency of serum IgA (< 2.5 IU/ml) and 15 partial deficiency (serum IgA below the 10th centile for age). Patients with another associated immunodeficiency, such as ataxia-telan giectasia, were not included. Most children with complete deficiency .of IgA had recurrent respiratory and/or gastrointestinal infections, about half with onset in the first year of life, while partial deficiency of IgA has probably little if any importance for anti-infectious immunity but is important in the pathogenesis of atopy. Atopic diseases were frequent in both groups. Chromosomal abnormalities Were found in 2 patients: trisomy 21 in one and in the other a ring chromosome 18. No important defects in cellular immunity were detected but some isolated, borderline abnormalities were often present.