Selective homing of phenotypically lytic cells within nasopharyngeal carcinoma biopsies: Numerous CD8- and CD16-positive cells in the tumor
✍ Scribed by M. Lakhdar; M. H. Ben Aribia; M. Maalej; A. Ladgham
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- French
- Weight
- 544 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
We present a comparative analysis of cell‐mediated immunity between circulating lymphocytes and tumor‐infiltrating lymphocytes (TIL) from patients with nasopharyngeal carcinoma (NPC). Phenotypic analysis using a panel of monoclonal antibodies (MAbs) to define lymphocytic subsets has revealed a selective homing of phenotypically lytic cells such as CD8‐and CD 16‐positive cells, but a low percentage of macrophages when compared to PBL of NPC patients. Also, PBL and TIL contain an equivalent percentage of activated T‐lymphocytes expressing HLA‐DR molecules and IL‐2 receptors. Functionally, TIL exhibit an abolished NK‐cell activity and concomitant decrease of proliferative response to phytohemaglutinin (PHA) and concanavalin A (ConA) stimulation when compared with PBL.