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Selective HDAC1/HDAC2 Inhibitors Induce Neuroblastoma Differentiation

✍ Scribed by Frumm, Stacey M.; Fan, Zi Peng; Ross, Kenneth N.; Duvall, Jeremy R.; Gupta, Supriya; VerPlank, Lynn; Suh, Byung-Chul; Holson, Edward; Wagner, Florence F.; Smith, William B.; Paranal, Ronald M.; Bassil, Christopher F.; Qi, Jun; Roti, Giovanni; Kung, Andrew L.; Bradner, James E.; Tolliday, Nicola; Stegmaier, Kimberly


Book ID
120937435
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
798 KB
Volume
20
Category
Article
ISSN
1074-5521

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## Abstract Human securin regulates correct chromatid separation. However, there are conflicting reports on the aneugenic effects of its gene deletion. Here we show that __PTTG1__/securin gene expression is dramatically repressed when Hsp90 or histone deacetylases are inhibited. However, these trea